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Fig. 12 Telmisartan proposed mechanism of action. Blue arrows correspond to the direction of the metabolic flux following telmisartan treatment. Grey and blue sings next to the metabolites indicate the metabolomic analysis results for the HFHFr and Tel groups respectively. 1,3-p-GA: 1,3-phosphoglyceric acid; 2/3-PG: 2/3-phosphoglyceric acid; DHAP: dihydroxyacetone phosphate; F-1-p: fructose 1-phosphate; F-1,6-p: fructose 1,6-diphosphate; F-6-p: fructose 6-phosphate; G-6-p: glucose 6-phosphate; GA3P: glyceraldehyde 3-phosphate; GSH: reduced glutathione; GSSG: oxidized glutathione; OAA: oxalacetate; PCK1: phosphoenolpyruvate carboxykinase 1; PEP: phosphoenolpyruvic acid; PRPP: phosphoribosyl pyrophosphate.