ZFIN Image: Babu et al., 2025, Fig. 1

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Figure Caption

Fig. 1 Zebrafish model recapitulates localization of human MM. A Light micrographs of zebrafish melanoma generated from melanocyte-specific expression or CRISPR-deletion in transparent “Casper” zebrafish. Cutaneous model (upper). Mucosal model (lower). B MM free survival of zebrafish with melanocyte-specific expression of human CCND1 and melanocyte-specific CRISPR-deletion of pten a and b and tp53. C–G Zebrafish melanoma histology. CM n = 4, MM n = 5. C, D H&E stain of MM (C) and CM (D). E, F Phospho ERK (pERK) immunohistochemistry (IHC) of MM (E) and CM (F). Scale bar = 1 mm; inset scale bar = 100 μm. Black arrow = tumor, red arrow = brain. G Quantification of % pERK positive zebrafish melanomas. H % zebrafish MM penetrance. n = zebrafish.

Acknowledgments

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