Fig. 5
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Fig. 5 Flnc deficiency resulted in impaired mitochondrial dynamics. (A) Colocalization of F-actin, filamin-C, and Drp1 in wild-type zebrafish. (B) Coimmunoprecipitation of actin and Drp1 from lysates from MO and COMO zebrafish. IgG was used as an IP negative control. The data showed that the ability of Drp1 to bind to actin was weakened in the MO zebrafish. (C) Compared with the CoMO group, the MO group exhibited significantly increased expression of Drp1 and Opa1. All the data are shown as the means ± SDs. *P < 0.05, **P < 0.01, ***P < 0.001. Statistical significance was calculated via Student’s two-tailed t test.