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ZIRC
ZFIN ID: ZDB-GENE-041114-7
Gene Name: OPA1 mitochondrial dynamin like GTPase
Gene Symbol: opa1    Nomenclature History

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Previous Names: fk62d06, wu:fb77a10, wu:fk62d06, zgc:92092

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have GTPase activity; microtubule binding activity; and phospholipid binding activity. Involved in chordate embryonic development; mitochondrion morphogenesis; and ventricular cardiac muscle cell development. Predicted to localize to the mitochondrial membrane. Human ortholog(s) of this gene implicated in dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; and optic atrophy. Is expressed in retina. Orthologous to human OPA1 (OPA1 mitochondrial dynamin like GTPase).
Genome Resources: Alliance (1),  Gene:492332 (1),  Ensembl(GRCz11):ENSDARG00000070801 (2)
GENE EXPRESSION
All Expression Data: 10 figures from 8 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7155623]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7157256]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ws1357Tg Transgenic Insertion Intron 27 Unknown DNA
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-opa1 N/A 2
    MO2-opa1 N/A 1
    DISEASE ASSOCIATED WITH opa1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    dominant optic atrophy plus syndrome Alliance Optic atrophy plus syndrome 125250
    mitochondrial DNA depletion syndrome 14 Alliance ?Mitochondrial DNA depletion syndrome 14 (encephalocardiomyopathic type) 616896
    optic atrophy 1 Alliance Optic atrophy 1 165500
    Behr syndrome 210000
    {Glaucoma, normal tension, susceptibility to} 606657
    DISEASE ASSOCIATED WITH opa1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function cardiolipin binding (more)
    GO Terms (all 29)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA opa1-201 (1)    Ensembl 4305
    opa1-202 (1)    Ensembl 1463
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-opa1 monoclonal IgG1 Mouse IHC BD Biosciences
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM opa1 No data available
    MARKER RELATIONSHIPS
    opa1 Contained in: [BAC] CH211-196H19 (1) (order this), DKEY-18A23 (1) (order this)
    opa1 Encodes: [EST] fb77a10, fk62d06 (1), IMAGE:7155623 (1) (order this), IMAGE:7157256 (1) (order this)
    [cDNA] MGC:92092 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001007298 (1) 4296 bp
    Genomic GenBank:BX004839 (1) 223000 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IJ30 (1) 1034 aa
    Sequence Clusters UniGene:37656 (1)
    Sequence Information (all 35)
    ORTHOLOGY for opa1 ( Chr: 6 )
    CITATIONS (37)