Gene

opa1

ID

ZDB-GENE-041114-7

Name

OPA1 mitochondrial dynamin like GTPase

Symbol

opa1 Nomenclature History

Previous Names

fk62d06
wu:fb77a10
wu:fk62d06
zgc:92092

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have GTPase activity; microtubule binding activity; and phospholipid binding activity. Involved in chordate embryonic development; mitochondrion morphogenesis; and ventricular cardiac muscle cell development. Predicted to localize to several cellular components, including cytoplasmic vesicle; microtubule cytoskeleton; and mitochondrial membrane. Human ortholog(s) of this gene implicated in Behr syndrome; dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; optic atrophy; and optic atrophy 1. Is expressed in retina. Orthologous to human OPA1 (OPA1 mitochondrial dynamin like GTPase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 13 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7155623 (1 image)
IMAGE:7157256 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With opa1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Behr syndrome	Alliance	Behr syndrome	210000
dominant optic atrophy plus syndrome	Alliance	Optic atrophy plus syndrome	125250
mitochondrial DNA depletion syndrome 14	Alliance	?Mitochondrial DNA depletion syndrome 14 (encephalocardiomyopathic type)	616896
optic atrophy 1	Alliance	Optic atrophy 1	165500
		{Glaucoma, normal tension, susceptibility to}	606657

Associated With opa1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001401	Dynamin, GTPase domain
Domain	IPR030381	Dynamin-type guanine nucleotide-binding (G) domain
Domain	IPR045063	Dynamin, N-terminal
Domain	IPR045817	Dynamin-like GTPase OPA1, C-terminal
Family	IPR022812	Dynamin
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	Dynamin	Dynamin, GTPase domain	Dynamin-like GTPase OPA1, C-terminal	Dynamin, N-terminal	Dynamin-type guanine nucleotide-binding (G) domain	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M6Z7B4 InterPro	1033
UniProtKB:A0A8M9Q626 InterPro	982
UniProtKB:Q5U3A7 InterPro	966
UniProtKB:A0A8M9QFC7 InterPro	911
UniProtKB:A0A8M9QFC3 InterPro	1034
UniProtKB:A0A8M9PM18 InterPro	1018
UniProtKB:A0A8M9PZN8 InterPro	1017

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	opa1-201 (1) Ensembl	Ensembl	4,305 nt	Select Tool ZFIN BLAST
mRNA	opa1-202 (1) Ensembl	Ensembl	1,463 nt	Select Tool ZFIN BLAST
mRNA	opa1-203 (1) Ensembl	Ensembl	6,746 nt	Select Tool ZFIN BLAST
mRNA	opa1-204 (1) Ensembl	Ensembl	6,629 nt	Select Tool ZFIN BLAST
mRNA	opa1-205 (1) Ensembl	Ensembl	6,698 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab2-opa1	monoclonal	opa1	IgG1	Mouse	IHC	BD Biosciences	2
Ab3-opa1	monoclonal	opa1	IgG1	Mouse	WB	BD Biosciences	3

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations