Gene

dnm1l

ID
ZDB-GENE-040426-1556
Name
dynamin 1-like
Symbol
dnm1l Nomenclature History
Previous Names
  • zgc:66163 (1)
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have GTPase activity; microtubule binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including dynamin family protein polymerization involved in mitochondrial fission; intracellular distribution of mitochondria; and mitochondrial fragmentation involved in apoptotic process. Predicted to localize to cytosol; mitochondrial outer membrane; and peroxisome. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 and optic atrophy 5. Is expressed in brain. Orthologous to human DNM1L (dynamin 1 like).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dnm1l Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
encephalopathy due to defective mitochondrial and peroxisomal fission 1 Alliance Encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1 614388
optic atrophy 5 Alliance Optic atrophy 5 610708
Associated With dnm1l Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019762 Dynamin, GTPase region, conserved site
Domain IPR000375 Dynamin stalk domain
Domain IPR001401 Dynamin, GTPase domain
Domain IPR003130 Dynamin GTPase effector
Domain IPR020850 GTPase effector domain
Domain IPR030381 Dynamin-type guanine nucleotide-binding (G) domain
Family IPR030556 Dynamin-1-like protein
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length Dynamin-1-like protein Dynamin, GTPase domain Dynamin GTPase effector Dynamin, GTPase region, conserved site Dynamin stalk domain Dynamin-type guanine nucleotide-binding (G) domain GTPase effector domain P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F1Q917 228
UniProtKB:A0A140LH30 715
UniProtKB:Q7SXN5 691
UniProtKB:F1QB59 94
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations