Gene
dnm1l
- ID
- ZDB-GENE-040426-1556
- Name
- dynamin 1-like
- Symbol
- dnm1l Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have GTPase activity; microtubule binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including dynamin family protein polymerization involved in mitochondrial fission; intracellular distribution of mitochondria; and mitochondrial fragmentation involved in apoptotic process. Predicted to localize to cytosol; mitochondrial outer membrane; and peroxisome. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 and optic atrophy 5. Is expressed in brain. Orthologous to human DNM1L (dynamin 1 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| encephalopathy due to defective mitochondrial and peroxisomal fission 1 | Alliance | Encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1 | 614388 |
| optic atrophy 5 | Alliance | Optic atrophy 5 | 610708 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019762 | Dynamin, GTPase region, conserved site |
| Domain | IPR000375 | Dynamin stalk domain |
| Domain | IPR001401 | Dynamin, GTPase domain |
| Domain | IPR003130 | Dynamin GTPase effector |
| Domain | IPR020850 | GTPase effector domain |
| Domain | IPR030381 | Dynamin-type guanine nucleotide-binding (G) domain |
| Domain | IPR045063 | Dynamin, N-terminal |
| Family | IPR022812 | Dynamin |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | Dynamin | Dynamin, GTPase domain | Dynamin GTPase effector | Dynamin, GTPase region, conserved site | Dynamin, N-terminal | Dynamin stalk domain | Dynamin-type guanine nucleotide-binding (G) domain | GTPase effector domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BA46
|
703 | |||||||||
|
UniProtKB:Q7SXN5
|
691 | |||||||||
|
UniProtKB:A0A140LH30
|
715 | |||||||||
|
UniProtKB:A0A8M2BAD6
|
727 |
Interactions and Pathways
No data available
Plasmids
No data available