ZFIN Image: Evans et al., 2025, Fig. 7

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Figure Caption

Fig. 7

Analysis of the set of genes in the wider transcriptome shows a 27.8-fold increase in the KD ZF. (A) Identification of peripheral elements underpinning the hypergraph implicates a wider set of genes than the initial targets. A summary of those peripheral elements is presented here. (B, C) Venn diagrams of genes positively (B) and negatively (C) correlating with age. (D, E) Hierarchically clustered heat maps of gene expression of the genes identified in the wider transcriptome. Gene expression in the standard control (D) cluster into two age related groups, whereas expression in the knockdown (E) show significant dysregulation. (F, G) Gene set enrichment analysis (GSEA) ranked by R-value of rank age regression in the standard control (F) and knockdown (G). (H) GSEA ranked by R-value of rank age regression of the cluster of genes in the white box in (E)

Acknowledgments

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