ZFIN Image: Li et al., 2025, Figure 4

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Figure Caption

Figure 4

GO enrichment and KEGG pathway analysis of differentially expressed genes (DEGs), and transcriptional and qPCR validation of key genes in Lurasidone-treated zebrafish embryos. (A, B) Top 10 GO terms for up-regulated and down-regulated DEGs categorized into biological processes (BP), molecular functions (MF), and cellular components (CC). Adjusted p-values (padj) were used to assess statistical significance. (C, D) KEGG pathway enrichment analysis of up-regulated and down-regulated DEGs with p-values indicating pathway significance. (E) Heatmap of transcriptomics data displaying normalized expression levels of selected key genes. (F, G) qPCR validation results for the same set of genes, presented as mean ± S.E. with statistical significance denoted as *P < 0.05, **P < 0.01, and ***P < 0.001.

Acknowledgments

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