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Fig. 8 Effect of IC treatment on pro-inflammatory gene expression and Cd-treated renal tissue morphology. (Cd denotes Cadmium; RIPM denotes Rapamycin; TD denotes tubular degeneration; TDO denotes tubular disorganization; GDO denotes glomerular disorganization; HDTC denotes hyaline degeneration of tubular cells; NDTC denotes nuclear degeneration of tubular cells) (a) H&E staining of adult zebrafish intestine (a.1) Control (a.2) Cd (a.3) RIPM (2.5 Μm) (a.4) Cd+IC (100 µM) (a.5) Cd+IC (150 µM) (b) Gene expression levels of TNF-α (c) IL-1β (d) IL-6 (e) NF-κB. Triplicate experiments were conducted, and the results are represented as mean ± SD. The asterix (*) denotes the significance level compared to the control group. *p < 0.0332, **p < 0.0021, ***p < 0.0002, and ****p < 0.0001.