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Le et al., 2025 - A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression

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FIGURE 10

c1q levels measured by RT-qPCR in control and crim1^−/− larvae that are homozygous for a 2 base pair deletion, c.339_340delCT p.Leu112Leufs*3, at 72 h post fertilization (hpf). RT-qPCR showing expression of c1qa, c1qb, c1qc, cd74a, and cd74b in crim1^−/− larvae compared to controls. RT-qPCR was performed on dissected eyes for all experiments from control (white columns; expression normalized to 1.0) and crim1^−/− larvae (black columns) at 72 hpf. The results show significantly increased expression of c1qb (P = 0.018) and significantly reduced expression of c1qc (P = 0.003) and cd74b (P = 0.032) in crim1^−/− larvae compared to controls. c1qa (P = 0.154) and cd74a (P = 0.391) expression was not significantly different.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol