Gene
cd74b
- ID
- ZDB-GENE-990910-10
- Name
- CD74 molecule, major histocompatibility complex, class II invariant chain b
- Symbol
- cd74b Nomenclature History
- Previous Names
-
- cd74
- Iclp-2
- iclp2
- zgc:123161
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable MHC class II protein binding activity; cytokine receptor activity; and macrophage migration inhibitory factor binding activity. Acts upstream of or within inner ear development and neuromast development. Predicted to be located in extracellular region and membrane. Predicted to be active in cell surface and cytoplasm. Is expressed in inner ear and otic vesicle. Orthologous to human CD74 (CD74 molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa14165 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-cd74b | N/A | Shen et al., 2012 |
| MO2-cd74b | N/A | Serbanovic-Canic et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000716 | Thyroglobulin type-1 |
| Domain | IPR015386 | MHC class II-associated invariant chain/CLIP, MHC II-interacting |
| Family | IPR043530 | HLA class II histocompatibility antigen, gamma subunit |
| Family | IPR052001 | MHC Class II Gamma Chain/Thyroglobulin |
| Homologous_superfamily | IPR036857 | Thyroglobulin type-1 superfamily |
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Domain Details Per Protein
| Protein | Length | HLA class II histocompatibility antigen, gamma subunit | MHC class II-associated invariant chain/CLIP, MHC II-interacting | MHC Class II Gamma Chain/Thyroglobulin | Thyroglobulin type-1 | Thyroglobulin type-1 superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:Q9PVD9
|
198 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-42P12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:123161 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152708 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158213 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158500 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131372 (1) | 1049 nt | ||
| Genomic | GenBank:CU915785 (2) | 83275 nt | ||
| Polypeptide | UniProtKB:Q9PVD9 (1) | 198 aa |
- Wang, A., Wan, X., Zhuang, P., Jia, W., Ao, Y., Liu, X., Tian, Y., Zhu, L., Huang, Y., Yao, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Jiao, J., Zhang, Y. (2023) High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation. Proceedings of the National Academy of Sciences of the United States of America. 120:e2221097120e2221097120
- Yu, F., Luo, H.R., Cui, X.F., Wu, Y.J., Li, J.L., Feng, W.R., Tang, Y.K., Su, S.Y., Xiao, J., Hou, Z.S., Xu, P. (2022) Changes in aggression and locomotor behaviors in response to zinc is accompanied by brain cell heterogeneity and metabolic and circadian dysregulation of the brain-liver axis. Ecotoxicology and environmental safety. 248:114303
- Demin, K.A., Lakstygal, A.M., Krotova, N.A., Masharsky, A., Tagawa, N., Chernysh, M.V., Ilyin, N.P., Taranov, A.S., Galstyan, D.S., Derzhavina, K.A., Levchenko, N.A., Kolesnikova, T.O., Mor, M.S., Vasyutina, M.L., Efimova, E.V., Katolikova, N., Prjibelski, A.D., Gainetdinov, R.R., de Abreu, M.S., Amstislavskaya, T.G., Strekalova, T., Kalueff, A.V. (2020) Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish. Scientific Reports. 10:19981
- Demirci, Y., Cucun, G., Poyraz, Y.K., Mohammed, S., Heger, G., Papatheodorou, I., Ozhan, G. (2020) Comparative Transcriptome Analysis of the Regenerating Zebrafish Telencephalon Unravels a Resource With Key Pathways During Two Early Stages and Activation of Wnt/β-Catenin Signaling at the Early Wound Healing Stage. Frontiers in cell and developmental biology. 8:584604
- Cao, L., Wu, X.M., Nie, P., Chang, M.X. (2019) The negative regulation of piscine CD44c in viral and bacterial infection. Developmental and comparative immunology. 96:135-143
- Cosacak, M.I., Bhattarai, P., Reinhardt, S., Petzold, A., Dahl, A., Zhang, Y., Kizil, C. (2019) Single-Cell Transcriptomics Analyses of Neural Stem Cell Heterogeneity and Contextual Plasticity in a Zebrafish Brain Model of Amyloid Toxicity. Cell Reports. 27:1307-1318.e3
- Meguro, S., Hosoi, S., Hasumura, T. (2019) High-fat diet impairs cognitive function of zebrafish. Scientific Reports. 9:17063
- Dijkstra, J.M., Yamaguchi, T. (2018) Ancient features of the MHC class II presentation pathway, and a model for the possible origin of MHC molecules. Immunogenetics. 71(3):233-249
- Liu, H., Wang, X., Wu, Y., Hou, J., Zhang, S., Zhou, N., Wang, X. (2018) Toxicity responses of different organs of zebrafish (Danio rerio) to silver nanoparticles with different particle sizes and surface coatings. Environmental pollution (Barking, Essex : 1987). 246:414-422
- Chernyavskaya, Y., Mudbhary, R., Tokarz, D., Jacob, V., Gopinath, S., Zhang, C., Sun, X., Wang, S., Magnani, E., Madakashira, B.P., Yoder, J.A., Hoshida, Y., Sadler, K.C. (2017) Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling. Development (Cambridge, England). 144(16):2925-2939
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