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Fig. 1 High circulating lactate in MF sera favors immune deregulation. (A) Evaluation of Lactate concentration in PB from healthy and PMF patients. (B) Analysis of the percentage of Treg and (D) M-MDSCs after culturing healthy PBMCs with HC or PMF serum. (C) Evaluation of 10 ?M AZD3965 effects on circulating lactate-induced Treg and (E) M-MDSC expansion. Data are presented as means?±?SD. ***p?
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