Thyroid status modifies the number of GCL axons but not the morphology of the optic tectum. (A) Illustrative representations of the zebrafish larvae eye indicating the optic nerve (ON) area photographed in (C,D). (B) Dorsal view representation to depict the Fmyelin stained area in (E). (C) Transmission electron micrographs of the optic nerve at 5 dpf and (D) their corresponding threshold. Axons crossing the optic nerve are fewer after IOP treatment, as indicated with the red arrows in (D). (E) Maximum intensity projections of the Fmyelin staining in the optic tectum (OT, circled in dotted line). Quantification from left and right OT is shown as integraded density (I.D.) from a Z-projection. Bars represent the mean ± SEM. n = 6 animals per group. Scale bar = 2 µm in (C) and 10 µm in (E).
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Full text @ Int. J. Mol. Sci.
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