Global overview of differential gene expression after camptothecin (CPT) treatment of zebrafish embryos. (A) Heatmap plot of all DEGs after CPT treatment. Standard hierarchical clustering was performed of the variance-stabilized values which were scaled row-wise for visualization. Treatment and genotype factors are indicated in the heatmap. Numbers of up- and down-regulated genes are indicated in the side panel of the heatmap. (B) MA plot of all genes with non-DEG genes labeled in grey, up-regulated genes in red and down-regulated in blue. The names of top 80 DEGs are indicated directly on the plot. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
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