Figure 4.

Figure 4.

Spectral ERG measurements of the peak b-wave response in mglur6a and mglur6b mutant fish. The peak b-wave amplitude was quantified at five different light intensity stimuli, at different spectral wavelengths. (A–D) The peak b-wave measured in 5 dpf mglur6a mutant fish. There is no significant difference between wild-type and KO fish in any of the various spectra (see Materials and Methods for wavelengths of various stimuli). (A) White light stimulus. (B) Red light stimulus. (C) Green light stimulus. (D) UV/blue light stimulus. (E–H) The peak b-wave measured in 5 dpf mglur6b mutant fish. mglur6b^–/– fish show a significantly decreased b-wave amplitude in response to all stimuli. (E) White light stimulus. (F) Red light stimulus. (G) Green light stimulus. (H) UV/blue light stimulus. (I–L) The peak b-wave measured in adult mGluR6a mutant fish. There is no significant difference between wild-type and KO fish in any of the various spectra. (I) White light stimulus. (J) Red light stimulus. (K) Green light stimulus. (L) UV/blue light stimulus. (For all statistical data and significance, please see Supplementary Table S3.)