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Fig. 6 PI3K?Akt?mTOR signaling and RAS?RAF?MAPK signaling in vascular anomalies. Inhibitors of the signaling pathway are shown in red: PIK3CA inhibitor alpelisib (BYL719), Akt inhibitor MK-2206, and mTOR inhibitor rapamycin (sirolimus). Akt, protein kinase B; ERK, extracellular signal?regulated kinase; MEK, MAPK/extracellular signal?regulated kinase; PI3K, phosphoinositide 3-kinase.
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Full text @ J. Invest. Dermatol.