ZFIN Image: Gaitán-Peñas et al., 2024, Fig. 1

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Figure Caption

Fig. 1 GENOMIC ANALYSIS OF THE CLCN1 GENES A, genomic organization of the CLCN1 locus in humans (Hs), mice (Mm), zebrafish (Dr), nile tilapia (On) and mexican tetra (Amx). Several genes around the CLCN1 locus are conserved. B, alignment of the predicted protein sequences of human, mouse, and zebrafish ClC-1 channels performed with CLUSTALW. α-helices are labelled with a black line. The CBS (cystathionine β-synthase) intracellular domains are marked with a blue line. Residues involved in chloride selectivity are highlighted with green background. Exons are typed in alternate black and red. Asterisk indicates identical residues among the five proteins, colon indicates conserved residues, and full stop indicates similar residues.

Acknowledgments

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