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Fig. 4

ID

ZDB-IMAGE-240618-4

Antibodies

Ab2-lrp2

Publication

Bondue et al., 2024 - MFSD12 depletion reduces cystine accumulation without improvement in proximal tubular function in experimental models for cystinosis

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Figures for Bondue et al., 2024

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Figure Caption

Fig. 4 mfsd12a knockdown cannot ameliorate the proximal tubular dysfunction in ctns−/− zebrafish. A: morpholino-treated zebrafish were injected with 4.4 kDa TRITC-dextran in the circulation at 72 h post-injection. Fluorescence of the proximal tubular region was evaluated after 60 min in relation to the mean fluorescence in the untreated fish. Significance was evaluated with a one-way ANOVA and mean with SE is indicated. Each dot represents a single tubular region from three to four individual fish. **P < 0.01. B and C: 72 h post-injection, zebrafish sections were stained with Hoechst-33342 (blue) and for megalin (green). Megalin-488 fluorescence was quantified for each tubule (n = 7–15 fish/group), and significance was tested with a Kruskal–Wallis test. Scale bar = 20 µm. **P < 0.01.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Am. J. Physiol. Renal Physiol.