Fig. 11 Cell viability comparison between HMEC-1 and MDA-MB-231 cell lines upon treatment with various doses of L3, L5, 6, and 12 for 72 h. (A) L3 showing lower toxicity toward HMEC-1 compared to MDA-MB-231. (B) L5 showing closely similar toxicity profile toward HMEC-1 and MDA-MB-231. (C) Complexes 6 and 12 showing a significantly lower toxicity toward HMEC-1 compared to MDA-MB-231 and unable to kill beyond 50% even at a 100 μM dose. A comparison of the data for L5 in (B) and its complex 12 in (C) shows that the ligand is more toxic in vitro than the complex on HMEC-1 [the x-axis denotes the logarithmic concentration (nanomolar) of the compounds].
Image
Figure Caption
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ J. Med. Chem.