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Fig. 6 VD affected the functions related to the folate biosynthesis in gut commensals of zebrafish. A: the functional KEGG profiles of gut microbiota in wild-type and cyp2r1–/– zebrafish were predicted based on Tax4Fun analysis (LDA score > 2, P < 0.05). B: the heat-map was constructed to illustrate the differential abundance of the enzymes related to folate biosynthesis in wild-type and cyp2r1–/– zebrafish. The red and blue squares indicate the higher and lower abundance, respectively. C: the Spearman’s correlation between the predicted pathways of folate biosynthesis and the dominant genus in the gut microbiota was displayed. *P < 0.05; **P < 0.01; ***P < 0.001. D: the cladogram showing differentially abundant taxa in the gut microbiota of wild-type and cyp2r1–/– zebrafish. The enriched taxa in the wild-type (red) and cyp2r1–/– (blue) zebrafish were indicated. VD, vitamin D.