Fig. 1 The folate pathway in zebrafish was influenced by dietary VD3. A: volcano plot of differentially expressed genes (DEGs) in the visceral mass of zebrafish-fed diets with VD3 or without VD3. Each dot represents an individual gene (n = 9 fish). The red dots (top) indicate the significantly upregulated genes (P < 0.05), whereas the green dots (bottom) represent the significantly downregulated genes (P < 0.05). B: the top 20 KEGG pathways enriched for DEGs. Rich factor is the ratio of the number of DEGs enriched in a certain pathway to the total number of DEGs (n = 9 fish). C: the heat-map of DEGs related to the folate biosynthesis (n = 9 fish). VD, vitamin D.
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Full text @ Am. J. Physiol. Endocrinol. Metab.