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Fig. 1

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Publication: Nwagbo et al., 2024 - Elovl4b Knockout Zebrafish as a Model for Ocular Very-Long-Chain Polyunsaturated Fatty Acid Deficiency
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Fig. 1

VLC-PUFA biosynthetic pathways in mammals and zebrafish. Comparison of the VLC-PUFA biosynthetic pathways from linoleic (18:2n-6) and α-linolenic (18:3n-3) acid precursors of zebrafish and mammalian vertebrates (adapted from Refs. (10) and (13)). Large dashed black arrows represent the desaturation steps, small dashed arrows represent the β-oxidation steps, and solid arrows represent the elongation steps. AA, arachidonic acid; ALA, α-linolenic acid; LA, linoleic acid. Color key: red text: mammalian (human and murine) orthologues, blue text: zebrafish orthologues, and brown text and arrows: pathway presumed but not confirmed in zebrafish.

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