ZFIN Image: Sun et al., 2024, Figure 10

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Figure Caption

Figure 10

Effects of IWR-1-endo on components of the Wnt pathway in F0 amer1 knockdown embryos. (A,B) Western blotting and quantitation showing that β-catenin expression was lower in IWR-treated amer1 knockdown embryos than in amer1 knockdown embryos at 4 dpf. (C) qPCR showing that the levels of expression of lef1, jun, and fosl1a were lower in IWR-treated than in untreated amer1 knockdown embryos. (D) Co-localization of β-catenin with the cell nucleus in the ceratohyal cartilage was reduced in amer1 knockdown embryos treated with IWR. (E) Manual counting of co-localization of β-catenin with cell nuclei in embryos with different treatments (n = 3 each). * p < 0.05; ** p < 0.01; *** p < 0.001.

Acknowledgments

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