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Figure 7

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ZDB-IMAGE-231116-49

Antibodies

Publication

Taler et al., 2023 - Identification of Small Molecules for Prevention of Lens Epithelium-Derived Cataract Using Zebrafish

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Figures for Taler et al., 2023

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Figure Caption

Figure 7

mTOR signaling contributes to cell mass growth. (A,B) Confocal single-plane sections from eyes of 3 dpf plod3^vu222 larvae labeled for pS6K (green) and with 5E11 antibody that marks nuclei of ALE cells as well as a subset of amacrine cells (purple). pS6K staining in the mutant is increased in the developing mass and reduced in the ciliary marginal zones (marked by asterisks in (A)). White rectangles mark the ALE region. Scale bar is 50 µm. (C,D) Histological sections from eyes of 4 dpf plod3^vu222 larvae treated from 26 hpf until ~96 hpf with vehicle (C) or rapamycin (D). White lines mark the periphery of cellular masses. Scale bar is 20 µm. L, lens.

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