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Belcher et al., 2023 - The zebrafish paralog six2b is required for early proximal pronephros morphogenesis

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Figure 2

Pronephric marker expression following injection of six2b MO1. (a) Expression of pronephric markers at 24 hpf following MO1 injection. No significant changes in gene expression or tissue morphology were observed. (b) Expression of pronephric markers at 48 hpf following MO1 injection. Knock-down of six2b resulted in glomerular defects as seen with wt1a, nphs1, and nphs2. Proximal tubule morphogenesis was defective using cdh17 and slc20a1a probes. The proximal straight tubule appeared unaffected using trpm7. (c) Compiled data of wt1a morphological defects following mouse Six2 mRNA injection alone or combined with MO1. Six2 mRNA co-injection partially rescued the MO1 induced wt1a phenotype. Arrowheads for 48 hpf pax2a expression denote neck region.

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