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Sarkar et al., 2023 - Oxidative and Endoplasmic Reticulum Stress Represent Novel Therapeutic Targets for Choroideremia

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Figure 3

Analysis of ER stress in TUDCA-treated chm^ru848 fish and CHM^Y42X cells. Fish were treated with 20 µM of TUDCA or DMSO at 3 dpf and collected at 5 dpf for (A) retinal histology and (B) the RT-qPCR analysis of the ER stress markers atf6, bip and atf4. TUDCA reduces the expression of ER stress markers. (C) Cells were treated with either 100 µM of TUDCA or DMSO and the expression of the ER stress markers CHOP and BIP was analysed using RT-qPCR. Data are expressed as mean ± SEM from n = 3. * p ≤ 0.05, ** p ≤ 0.01, *** < p ≤ 0.001 **** p ≤ 0.0001. Scale bar (50 μm), shown in wt corresponds to all images in panel.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Antioxidants (Basel)