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Fig. 2
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Fig. 2
Induction of diabetes mellitus-like phenotypes in zebrafish larvae via combined treatment with GLU and STZ. (A) Relative mRNA expression of ins (n = 8 per group) and (B) Whole-body insulin level (n = 6 per group). (C) Relative mRNA expression of pck1 (n = 8 per group). (D) Whole-body glucose concentration (n = 6–8 per group). (E) Changes in whole-body glucose concentration after high-GLU challenge and (F) the corresponding AUC (n = 5 per group). (G) Relative gene expression of Ucn3 and (H) Slc30a8 (n = 8–11 per group). (I) Representative fluorescence microscopic image of pancreatic β-cells of the Tg (ins:EGFP) zebrafish larvae. Each group had 6–11 samples, with (A, B, and D-H) 10 or (C) 30 larvae per sample. Data are presented as mean ± standard deviation and each dot represents the value of each sample.
AUC = area under the curve; GLU = D-glucose; MAN = D-mannitol; STZ = streptozotocin; Tg = transgenic; EGFP = enhanced green fluorescent protein.
*p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 vs. indicated group.
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Full text @ Korean Circ J