Gene

slc30a8

ID
ZDB-GENE-060315-10
Name
solute carrier family 30 member 8
Symbol
slc30a8 Nomenclature History
Previous Names
  • wu:fe49g03
  • ZnT8 (1)
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have zinc ion transmembrane transporter activity. Involved in glucose homeostasis and type B pancreatic cell development. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including RPRD1A (regulation of nuclear pre-mRNA domain containing 1A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from O'Hare et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With slc30a8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
type 2 diabetes mellitus Alliance {Diabetes mellitus, noninsulin-dependent, susceptibility to} 125853
Associated With slc30a8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR002524 Cation efflux protein
Family IPR033572 Zinc transporter 8
Homologous_superfamily IPR027469 Cation efflux transmembrane domain superfamily
Homologous_superfamily IPR036837 Cation efflux protein, cytoplasmic domain superfamily
Domain Details Per Protein
Protein Length Cation efflux protein Cation efflux protein, cytoplasmic domain superfamily Cation efflux transmembrane domain superfamily Zinc transporter 8
UniProtKB:A0A2R8Q4D8 382
UniProtKB:A0A0R4IFM6 388
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations