Gene
slc30a8
- ID
- ZDB-GENE-060315-10
- Name
- solute carrier family 30 member 8
- Symbol
- slc30a8 Nomenclature History
- Previous Names
-
- wu:fe49g03
- ZnT8 (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable zinc ion transmembrane transporter activity. Acts upstream of or within glucose homeostasis and type B pancreatic cell development. Predicted to be located in nucleoplasm; plasma membrane; and transport vesicle membrane. Predicted to be part of transcription preinitiation complex. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RPRD1A (regulation of nuclear pre-mRNA domain containing 1A) and SLC30A8 (solute carrier family 30 member 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from O'Hare et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Diabetes mellitus, noninsulin-dependent, susceptibility to} | 125853 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006569 | CID domain |
| Domain | IPR032337 | RPRD1A/B, C-terminal domain |
| Domain | IPR047884 | RPRD1A, CID domain |
| Family | IPR002524 | Cation efflux protein |
| Family | IPR050681 | Cation Diffusion Facilitator/SLC30A |
| Homologous_superfamily | IPR008942 | ENTH/VHS |
| Homologous_superfamily | IPR027469 | Cation efflux transmembrane domain superfamily |
| Homologous_superfamily | IPR036837 | Cation efflux protein, cytoplasmic domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cation Diffusion Facilitator/SLC30A | Cation efflux protein | Cation efflux protein, cytoplasmic domain superfamily | Cation efflux transmembrane domain superfamily | CID domain | ENTH/VHS | RPRD1A/B, C-terminal domain | RPRD1A, CID domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32TDG6 | InterPro | 675 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc30a8-201
(1)
|
Ensembl | 3,839 nt | ||
| mRNA |
slc30a8-202
(1)
|
Ensembl | 1,149 nt |
Interactions and Pathways
No data available
Plasmids
No data available