Gene
slc30a8
- ID
- ZDB-GENE-060315-10
- Name
- solute carrier family 30 member 8
- Symbol
- slc30a8 Nomenclature History
- Previous Names
-
- wu:fe49g03
- ZnT8 (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have zinc ion transmembrane transporter activity. Involved in glucose homeostasis and type B pancreatic cell development. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including RPRD1A (regulation of nuclear pre-mRNA domain containing 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from O'Hare et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Diabetes mellitus, noninsulin-dependent, susceptibility to} | 125853 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cation efflux protein | Cation efflux protein, cytoplasmic domain superfamily | Cation efflux transmembrane domain superfamily | Zinc transporter 8 |
|---|---|---|---|---|---|
|
UniProtKB:A0A2R8Q4D8
|
382 | ||||
|
UniProtKB:A0A0R4IFM6
|
388 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
slc30a8-201
(1)
|
3839 nt |
Interactions and Pathways
No data available
Plasmids
No data available