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Fig. 5
Zebrafish hnf4a mutants exhibit the reduced expression of coagulation factor 2, but normal cholangiocyte-to-hepatocyte conversion. (A,B) Whole-mount in situ hybridization images show the expression of gc, f2, and f5 in regenerating livers (arrows) at R6h (A) and R24h (B). Graphs show the percentage of larvae that express gc (albumin counterpart in zebrafish), f2, or f5 in the regenerating liver. (C) Single-optical section images show the expression of fabp10a:CFP-NTR (blue), Tp1:H2B-mCherry (red), and betaine-homocysteine S-methyltransferase (Bhmt; gray) in regenerating livers at R24h. Numbers in the upper-right corner indicate the proportion of larvae exhibiting the expression/phenotype pattern shown. Scale bars: 100 μm (A,B) and 50 (C) μm. CFP, cyan fluorescent protein; NTR, nitroreductase; R, regenerating; WT, wild type
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