Gene
f2
- ID
- ZDB-GENE-030131-4606
- Name
- coagulation factor II (thrombin)
- Symbol
- f2 Nomenclature History
- Previous Names
-
- prothrombin (1)
- wu:fb57c10
- wu:fd42e09
- wu:fd59d01
- zgc:66319
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Acts upstream of or within blood coagulation. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in liver and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); appendicitis; artery disease (multiple); autoimmune disease (multiple); and thrombophilia (multiple). Orthologous to human F2 (coagulation factor II, thrombin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6903359 (6 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cerebral infarction | Alliance | {Stroke, ischemic, susceptibility to} | 601367 |
| prothrombin deficiency | Alliance | Dysprothrombinemia | 613679 |
| prothrombin deficiency | Alliance | Hypoprothrombinemia | 613679 |
| prothrombin thrombophilia | Alliance | Thrombophilia due to thrombin defect | 188050 |
| thrombophilia due to thrombin defect | Alliance | Thrombophilia due to thrombin defect | 188050 |
| {Pregnancy loss, recurrent, susceptibility to, 2} | 614390 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
| Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
| Conserved_site | IPR018056 | Kringle, conserved site |
| Domain | IPR000001 | Kringle |
| Domain | IPR000294 | Gamma-carboxyglutamic acid-rich (GLA) domain |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Domain | IPR018992 | Thrombin light chain |
| Family | IPR001314 | Peptidase S1A, chymotrypsin family |
| Family | IPR003966 | Prothrombin/thrombin |
| Family | IPR012224 | Peptidase S1A, coagulation factor VII/IX/X/C/Z |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR017857 | Coagulation factor-like, Gla domain superfamily |
| Homologous_superfamily | IPR035972 | Gamma-carboxyglutamic acid-rich (GLA) domain superfamily |
| Homologous_superfamily | IPR037111 | Thrombin light chain domain superfamily |
| Homologous_superfamily | IPR038178 | Kringle superfamily |
| Homologous_superfamily | IPR043504 | Peptidase S1, PA clan, chymotrypsin-like fold |
Domain Details Per Protein
| Protein | Length | Coagulation factor-like, Gla domain superfamily | Gamma-carboxyglutamic acid-rich (GLA) domain | Gamma-carboxyglutamic acid-rich (GLA) domain superfamily | Kringle | Kringle, conserved site | Kringle-like fold | Kringle superfamily | Peptidase S1A, chymotrypsin family | Peptidase S1A, coagulation factor VII/IX/X/C/Z | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Prothrombin/thrombin | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site | Thrombin light chain | Thrombin light chain domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1R704
|
539 | |||||||||||||||||
|
UniProtKB:A0A1D5NSK6
|
203 | |||||||||||||||||
|
UniProtKB:E7FAN5
|
635 | |||||||||||||||||
|
UniProtKB:Q7SXH8
|
524 |
Interactions and Pathways
No data available
Plasmids
No data available