Gene
f2
- ID
- ZDB-GENE-030131-4606
- Name
- coagulation factor II (thrombin)
- Symbol
- f2 Nomenclature History
- Previous Names
-
- prothrombin (1)
- wu:fb57c10
- wu:fd42e09
- wu:fd59d01
- zgc:66319
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Acts upstream of or within blood coagulation. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in liver and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including appendicitis; artery disease (multiple); autoimmune disease (multiple); hemophilia (multiple); and thrombophilia (multiple). Orthologous to human F2 (coagulation factor II, thrombin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6903359 (6 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cerebral infarction | Alliance | {Stroke, ischemic, susceptibility to} | 601367 |
| prothrombin deficiency | Alliance | Dysprothrombinemia | 613679 |
| prothrombin deficiency | Alliance | Hypoprothrombinemia | 613679 |
| prothrombin thrombophilia | Alliance | Thrombophilia 1 due to thrombin defect | 188050 |
| thrombophilia due to thrombin defect | Alliance | Thrombophilia 1 due to thrombin defect | 188050 |
| {Pregnancy loss, recurrent, susceptibility to, 2} | 614390 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
| Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
| Conserved_site | IPR018056 | Kringle, conserved site |
| Domain | IPR000001 | Kringle |
| Domain | IPR000294 | Gamma-carboxyglutamic acid-rich (GLA) domain |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Domain | IPR018992 | Thrombin light chain |
| Family | IPR001314 | Peptidase S1A, chymotrypsin family |
| Family | IPR003966 | Prothrombin/thrombin |
| Family | IPR012224 | Peptidase S1A, coagulation factor VII/IX/X/C/Z |
| Family | IPR051659 | Serine Protease S1 Domain-Containing Protein |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR017857 | Coagulation factor-like, Gla domain superfamily |
| Homologous_superfamily | IPR035972 | Gamma-carboxyglutamic acid-rich (GLA) domain superfamily |
| Homologous_superfamily | IPR037111 | Thrombin light chain domain superfamily |
| Homologous_superfamily | IPR038178 | Kringle superfamily |
| Homologous_superfamily | IPR043504 | Peptidase S1, PA clan, chymotrypsin-like fold |
Domain Details Per Protein
| Protein | Additional Resources | Length | Coagulation factor-like, Gla domain superfamily | Gamma-carboxyglutamic acid-rich (GLA) domain | Gamma-carboxyglutamic acid-rich (GLA) domain superfamily | Kringle | Kringle, conserved site | Kringle-like fold | Kringle superfamily | Peptidase S1A, chymotrypsin family | Peptidase S1A, coagulation factor VII/IX/X/C/Z | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Prothrombin/thrombin | Serine Protease S1 Domain-Containing Protein | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site | Thrombin light chain | Thrombin light chain domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SXH8 | InterPro | 524 | ||||||||||||||||||
| UniProtKB:E7FAN5 | InterPro | 635 |
Interactions and Pathways
No data available
Plasmids
No data available