Gene

f2

ID
ZDB-GENE-030131-4606
Name
coagulation factor II (thrombin)
Symbol
f2 Nomenclature History
Previous Names
  • prothrombin (1)
  • wu:fb57c10
  • wu:fd42e09
  • wu:fd59d01
  • zgc:66319
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have serine-type endopeptidase activity. Involved in blood coagulation. Predicted to localize to collagen-containing extracellular matrix and extracellular space. Is expressed in liver and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); appendicitis; artery disease (multiple); autoimmune disease (multiple); and thrombophilia (multiple). Orthologous to human F2 (coagulation factor II, thrombin).
Genome Resources
Note
None
Expression
All Expression Data
11 figures from 6 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With f2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cerebral infarction Alliance {Stroke, ischemic, susceptibility to} 601367
prothrombin deficiency Alliance Dysprothrombinemia 613679
prothrombin deficiency Alliance Hypoprothrombinemia 613679
prothrombin thrombophilia Alliance Thrombophilia due to thrombin defect 188050
thrombophilia due to thrombin defect Alliance Thrombophilia due to thrombin defect 188050
{Pregnancy loss, recurrent, susceptibility to, 2} 614390
Associated With f2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018114 Serine proteases, trypsin family, histidine active site
Active_site IPR033116 Serine proteases, trypsin family, serine active site
Conserved_site IPR018056 Kringle, conserved site
Domain IPR000001 Kringle
Domain IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
Domain IPR001254 Serine proteases, trypsin domain
Domain IPR018992 Thrombin light chain
Family IPR001314 Peptidase S1A, chymotrypsin family
Family IPR003966 Prothrombin/thrombin
Family IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
Homologous_superfamily IPR009003 Peptidase S1, PA clan
Homologous_superfamily IPR013806 Kringle-like fold
Homologous_superfamily IPR017857 Coagulation factor-like, Gla domain superfamily
Homologous_superfamily IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
Homologous_superfamily IPR037111 Thrombin light chain domain superfamily
Homologous_superfamily IPR038178 Kringle superfamily
Homologous_superfamily IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
Domain Details Per Protein
Protein Length Coagulation factor-like, Gla domain superfamily Gamma-carboxyglutamic acid-rich (GLA) domain Gamma-carboxyglutamic acid-rich (GLA) domain superfamily Kringle Kringle, conserved site Kringle-like fold Kringle superfamily Peptidase S1A, chymotrypsin family Peptidase S1A, coagulation factor VII/IX/X/C/Z Peptidase S1, PA clan Peptidase S1, PA clan, chymotrypsin-like fold Prothrombin/thrombin Serine proteases, trypsin domain Serine proteases, trypsin family, histidine active site Serine proteases, trypsin family, serine active site Thrombin light chain Thrombin light chain domain superfamily
UniProtKB:F1R704 539
UniProtKB:A0A1D5NSK6 203
UniProtKB:Q7SXH8 524
UniProtKB:E7FAN5 635
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations