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Figure 8
A proposed model explaining the role of ATX-LPA6 axis in formation and maintenance of plexus vessels
Plexus vessels are formed from pre-existing vessels both by sprouting and intussusceptive angiogenesis and the following constriction and separation of two pre-formed vessels. The present study proposes that an ATX-LPA6 axis contributes to vessels' constriction and separation, and also to maintain formed vessels downstream of ATX-LPA6-Gα13 signaling.
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