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FIGURE 8
Nxhl controls angiogenesis by targeting VE-PTP (ptprb)-related angiogenic genes. (A) Schematic model illustrating the mechanism of nxhl in zebrafish angiogenesis and heart development. The interactions between nxhl mRNA and NCL protein, NCL protein and ptprb mRNA are new-found interactions in this study. It connects with the keystone network of angiogenesis and heart development. (B) Possible mechanism of nxhl in zebrafish angiogenesis and heart development. Knockdown of nxhl may downregulate the nxhl-NCL-ptprb complex, subsequently regulate the proteins associated with angiogenesis and heart development, and finally result in heart pericardial edema, vascular patterning and integrity defects.