ZFIN Image: Karim et al., 2021, Fig 2

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Figure Caption

Fig 2 Oligomerization kinetics do not explain heterodimer-heterotetramer dominance.

A. Proportion of ligand-receptor tetrameric complexes at equimolar receptor at physiological conditions. The heterodimer-heterotetramer is only the fourth most abundant tetrameric complex. B. Proportion of ligand-receptor tetrameric complexes in a simulation with no homodimer ligand. Heterodimer-heterotetramer production is still not kinetically favored. C. Visualization of the prevalence of heterodimer-heterotetramer compared to other ligand-receptor tetramers in 3,375 points of a 84,375 point screen. The red region represents parameter space in which the heterodimer-heterotetramer is the most prevalent species (3.84% of this sample. D. The portion of the parameter space in which each ligand-receptor tetrameric complex is the most abundant. E. The portion of the parameter space in which the heterodimer-heterotetramer is the most abundant ligand-receptor tetrameric complex (5.66%) and the predominant tetrameric complex (0.0%).

Acknowledgments

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