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Figure 8
Schema of heteronemin-induced anti-lymphangiogenic mechanism in human lymphatic endothelial cells. This study reveals heteronemin as a promising anti-lymphangiogenic agent. Heteronemin may possess anti-lymphangiogenesis effect by reducing VEGFR-3 and its downstream NF-κB p65 and MEK/ERK signaling pathways and ARF-1, as well as the induction of VE-cadherin and the reduction in MMP-9 and vimentin, which is associated with EndoMT, in human lymphatic endothelial cells. T-shaped lines indicate inhibition.
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