Figure 6

Figure 6 Figure 6. Activity of VLX1570 in the zebrafish embryo model; (A) survival of zebrafish embryos exposed to the indicated concentrations of VLX1570 for 0–72 or 72–120 h; (B) examples of results obtained using labeled AML cells injected into zebrafish embryos followed by treatment with VLX1570; (C) effect of 1 µM VLX1570 on the growth and dissemination of injected AML cell lines in zebrafish embryos (student’s t test, ** p ≤ 0.01, *** p ≤ 0.001); and (D,E) effect of 1 µM VLX1570 on the growth and dissemination of injected primary AML cells in zebrafish embryos (student’s t test, * p ≤ 0.05, ** p ≤ 0.01).