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Figure 3
Chemically modified crRNA and tracrRNA duplex increased the ScCas9 efficiency. (A), Schematic illustration of the ScCas9 mdgRNP complex. The crRNA and tracrRNA scaffold with MS modified nucleotides (flag) at both termini coupled with the ScCas9 protein were loaded to the chromosome. (B), Statistics of gene editing efficiency induced by sgRNP, dgRNP and mdgRNP. ns, no significant difference; * p value < 0.05; ** p value < 0.01; *** p value < 0.001.
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