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Figure 3 Kinetics of ocular infection and granuloma formation in double-transgenic (cross-bred for kdrl and mpeg1: BB) larvae with wild-type Mycobacterium marinum (Mm). (A) Extracellular Mm (blue) lying in the lumen of retinal blood vessels at 1 dpi, and (B) crossing the vascular endothelium at 3 dpi. (C) The first appearance of phagocytosis inside the retinal tissue at 4 dpi, with the infected macrophage closely abutting the vascular endothelium, and (D) aggregation of macrophages into a granuloma within the retinal tissue at 6 dpi.
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