Figure 4—figure supplement 5.

Figure 4—figure supplement 5.

(A) Time series of the coupling strength κ with different DAPT washout time in the physical model. Black dashed lines indicate the increase of coupling strength over developmental stages in the absence of DAPT treatment. Red solid lines indicate coupling strength before and after DAPT washout. For simplicity, we assume that cells restore coupling to its original value immediately after washout as represented by the vertical red lines. (B) Dependence of times to FRS (blue) and PLD (green) on DAPT washout time in simulations. The box-whisker plot indicates (0.05, 0.25, 0.75, 0.95) quantiles of times to FRS and PLD for 100 realizations of simulations. The white bars indicate median. The effect of increasing coupling strength shown in (A) was examined with the constant PSM length and advection pattern. ss: somite stage.