ZFIN Image: Warchol et al., 2021, Figure 6

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Figure Caption

Figure 6

Selective depletion of macrophages in Tg(mpeg1:Gal4FF/UAS:NTR-mCherry) fish. Experiments utilized a transgenic fish line that expresses the bacterial enzyme NTR under the regulation of the Mpeg1 promoter (i.e., selectively in macrophages and microglia). Treatment of these fish with 0.1% DMSO did not affect the numbers of macrophages distributed within the posterior-most 500 μm of the spinal column (A,C). However, treatment for 24 h in 10 mM MTZ resulted in the nearly complete elimination of macrophages from this same region (B,C). Macrophage numbers remained low after 48 h recovery from MTZ treatment (C). Data obtained from 10 to 15 fish/treatment group.

Acknowledgments

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