ZFIN Image: Keefe et al., 2020, Figure 4

Image

Figure Caption

Figure 4 Top row (and quantification in lower left): increased apoptotic OPCs in the brain and spinal cord. Confocal images of brain, z-stack, rostral to the top, double-labeling for TUNEL and olig1 (in situ probe), in WT, eif2b5^zc103/zc103, eif2b5^zc102/zc102 or eif2b2^{sa17223/sa172233} larvae. Region used for quantification shown by box. Inset in each panel shows example of double-labeled cell (TUNEL, olig1) for each genotype (except WT), single confocal slice image. Middle panels: no change in apoptosis of differentiated oligodendrocytes, co-labeled with myelin associated glycoprotein (mag) (in situ probe) and TUNEL. Confocal z-stack images of spinal cord, rostral to the left; quantified in lower right panel.

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Acknowledgments

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