Gene
mag
- ID
- ZDB-GENE-041217-24
- Name
- myelin associated glycoprotein
- Symbol
- mag Nomenclature History
- Previous Names
-
- siglec-4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Enables carbohydrate binding activity and identical protein binding activity. Predicted to be involved in cell adhesion. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 75. Orthologous to human MAG (myelin associated glycoprotein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d821 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Djannatian et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 75 | Alliance | Spastic paraplegia 75, autosomal recessive | 616680 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Domain | IPR013106 | Immunoglobulin V-set domain |
| Family | IPR051036 | Sialic acid-binding Ig-like lectin |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain | Sialic acid-binding Ig-like lectin |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IQ16 | InterPro | 635 | ||||||||
| UniProtKB:A0A8M9QPU2 | InterPro | 567 | ||||||||
| UniProtKB:F1QSA4 | InterPro | 653 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mag-201
(1)
|
Ensembl | 539 nt | ||
| mRNA |
mag-202
(1)
|
Ensembl | 2,180 nt | ||
| mRNA |
mag-203
(1)
|
Ensembl | 2,496 nt | ||
| mRNA |
mag-204
(1)
|
Ensembl | 2,126 nt | ||
| mRNA |
mag-205
(1)
|
Ensembl | 2,212 nt | ||
| mRNA |
mag-206
(1)
|
Ensembl | 2,248 nt | ||
| mRNA |
mag-207
(1)
|
Ensembl | 2,351 nt | ||
| mRNA |
mag-208
(1)
|
Ensembl | 2,297 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-30E9 | ZFIN Curated Data | |
| Encodes | EST | 073-g06-2 | ZFIN Curated Data | |
| Encodes | cDNA | cssl:d821 | Bushell et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007062 (1) | 2180 nt | ||
| Genomic | GenBank:CT027647 (1) | 242225 nt | ||
| Polypeptide | UniProtKB:F1QSA4 (1) | 653 aa |
- Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):
- Wei, G., Zhang, X., Cai, C., Sheng, J., Xu, M., Wang, C., Gu, Q., Guo, C., Chen, F., Liu, D., Qian, F. (2022) Dual-Specificity Phosphatase 14 Regulates Zebrafish Hair Cell Formation Through Activation of p38 Signaling Pathway. Frontiers in Cellular Neuroscience. 16:840143
- Raby, L., Völkel, P., Hasanpour, S., Cicero, J., Toillon, R.A., Adriaenssens, E., Van Seuningen, I., Le Bourhis, X., Angrand, P.O. (2021) Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish. Cells. 10(11):
- Walter, K.M., Singh, L., Singh, V., Lein, P.J. (2021) Investigation of NH3 as a selective thyroid hormone receptor modulator in larval zebrafish (Danio rerio). Neurotoxicology. 84:96-104
- Keefe, M.D., Soderholm, H.E., Shih, H.Y., Stevenson, T.J., Glaittli, K.A., Bowles, D.M., Scholl, E., Colby, S., Merchant, S., Hsu, E.W., Bonkowsky, J.L. (2020) Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response. eLIFE. 9:
- Ling, Y., Sun, L., Wang, D., Jiang, J., Sun, W., Ai, W., Wang, X., Wang, H. (2020) Triclosan induces zebrafish neurotoxicity by abnormal expression of miR-219 targeting oligodendrocyte differentiation of central nervous system. Archives of toxicology. 94(3):857-871
- Chen, Z., Song, Z., Yang, J., Huang, J., Jiang, H. (2019) Sp7/osterix positively regulates dlx2b and bglap to affect tooth development and bone mineralization in zebrafish larvae. Journal of biosciences. 44(6):
- Djannatian, M., Timmler, S., Arends, M., Luckner, M., Weil, M.T., Alexopoulos, I., Snaidero, N., Schmid, B., Misgeld, T., Möbius, W., Schifferer, M., Peles, E., Simons, M. (2019) Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS. Nature communications. 10:4794
- Nagarajan, B., Harder, A., Japp, A., Häberlein, F., Mingardo, E., Kleinert, H., Yilmaz, Ö., Zoons, A., Rau, B., Christ, A., Kubitscheck, U., Eiberger, B., Sandhoff, R., Eckhardt, M., Hartmann, D., Odermatt, B. (2019) CNS myelin protein 36K regulates oligodendrocyte differentiation through Notch. Glia. 68(3):509-527
- Walter, K.M., Miller, G.W., Chen, X., Yaghoobi, B., Puschner, B., Lein, P.J. (2018) Effects of Thyroid Hormone Disruption on the Ontogenetic Expression of Thyroid Hormone Signaling Genes in Developing Zebrafish (Danio rerio). General and comparative endocrinology. 272:20-32
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