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Wu et al., 2020 - Low Molecular Weight Fucoidan Prevents Radiation-Induced Fibrosis and Secondary Tumors in a Zebrafish Model

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Figure 9

Upregulations of hnf4a, ddah1, 11b-hsd1, asgpr1, and hnf4a downstream target genes: tdo2a, in zebrafish after irradiation. (A) Gene expression profiles of hnf4a, ddah1, 11b-hsd1 and (B) zhi (asgpr1), tdo2a in WT zebrafish irradiation (WT + 10 Gy) and Oligo-Fucoidan pretreatment (WT + OF + R). (C) Positive correlations between zhi (asgpr1) and tdo2a were shown. (D) Gene expression profiles of hnf4a, ddah1, 11b-hsd1 and (E) zhi (asgpr1), tdo2a in HBx,src,p53-transgenic fish with diet-induced obesity plus 10 Gy irradiation (DIO + 10 Gy) or treatment of Oligo-Fucoidan before 10 Gy irradiation (DIO + OF + 10 Gy). (F) Positive correlations between zhi (asgpr1) and tdo2a were shown. Statistical significance was calculated by t-test (* p ≤ 0.05, ** p ≤ 0.01).

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