ZFIN Image: R�ltgen et al., 2020, FIGURE 3

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Figure Caption

FIGURE 3

Early host immune response to M. ulcerans infection illustrated in histological sections of a nodular lesion 6 weeks after subcutaneous infection of pigs (A–D) (from Bolz et al., 2016b) and in a sketch depicting the cellular composition of the lesion (E) (created with biorender.com). Histopathological analysis of pig lesions shows a central necrotic core containing extracellular M. ulcerans bacilli (A1,A2; AFB stained with Ziehl–Neelsen staining) and neutrophilic debris (B1,B2). The necrotic core is surrounded by layers of neutrophils (B1,B2) and macrophages (C1,C2), heavily interspersed with T-cells (D1,D2).

Acknowledgments

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