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Figure 2—figure supplement 1.

ID: ZDB-IMAGE-200530-39
Publication: Ye et al., 2020 - Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration
All Figures: Figures for Ye et al., 2020

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Figure Caption

Figure 2—figure supplement 1. <italic>lin28a</italic> was induced by various kinds of injury and <italic>lin28a</italic> expression level was proportional to injury size.

(A) RNA-Seq analysis using neomycin-treated neuromast cells revealed that lin28a was highly induced at 1 hr post neo while lin28b expression wa s not changed. (B) lin28a was induced at 1 hr post treatments with neomycin, cisplatin and copper. (C) LY-treated larvae were subjected for laser scan to ablate HCs at the indicated locations (white circles). Expression levels of lin28a was proportional to the injured cell number manipulated by laser ablation. (D) Laser was targeted at the circles for ablating indicated number of HCs or SCs. The corresponding neuromast was performed for lin28a in situ, and the results showed that either HC damage or SC damage could induce lin28a expression. Scale bar equals 10 μm.

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