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Zhao et al., 2020 - Copper induce zebrafish retinal developmental defects via triggering stresses and apoptosis

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Fig. 5

Rescue of retinal defects with the addition of ROS scavenger and ER stress scavenger. ROS scavengers GSH & NAC and ER scavenger PBA recovered the copper induced small eye defects (A) and the expression of retinal markers opn1sw2 (B1-B5) & opn1lw1 (C1-C5 and D1-D5) in copper-stressed embryos. E ROS scavengers GSH significantly neutralized copper induced cell apoptosis in embryos. Average number of apoptotic cells of retinal sections in each group (E10) (n > 3, 3–5 sections from each embryo were used for counting the red positive apoptotic cells). B1-B5, C1-C5, and D1-D5, dorsal view, anterior to the up; E1- E9, sagittal slides in eyes domain. Scale bar, A, B1-B5, C1-C5, and D1-D5, 100 μm; E1-E9, 50 μm. **, P < 0.01; *, P < 0.05

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