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Eskova et al., 2019 - Galanin Signaling in the Brain Regulates Color Pattern Formation in Zebrafish

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Figure 4

Galanin Receptor 1A Is Mutated in npm

(A) Phenotypes of npm (A1) and CRISPR-Cas9 induced frameshift mutations in galr1A (A2), galn (A4), and a trans-heterozygous fish galr1A/npm (A3) (see also Figures S2, S3, and S4).

(B) T4 thyroid hormone levels measured in wild-type, galn, and npm mutants (mean ± SD, n = 6 for WT, n = 5 for galn, n = 4 for npm).

(C–E) Relative transcript abundance for thyroglobulin (tg; C), thyroid-stimulating hormone (tshba; D), and thyrotropin-releasing hormone (trh; E) in the heads of galn (n = 8) and npm (n = 7) mutant fish compared to wild-type (n = 9). The plots depict the mean values (horizontal line), the first and third quartiles (box), and the lowest and highest values no further than 1.5 × IQR (interquartile range) from the hinge (whiskers); outliers are plotted as individual points (^∗p < 0.09; ^∗∗p < 0.05; ^∗∗∗p < 0.01; n.s., not significant).

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Acknowledgments

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