Gene
tshba
- ID
- ZDB-GENE-030513-3
- Name
- thyroid stimulating hormone subunit beta a
- Symbol
- tshba Nomenclature History
- Previous Names
-
- tshb (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity. Acts upstream of or within development of secondary sexual characteristics and regulation of thyroid hormone generation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in adenohypophyseal placode; head; hypophysis; and thyroid follicle. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 4 and hypothyroidism. Orthologous to human TSHB (thyroid stimulating hormone subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 51 figures from 35 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Song et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nongoitrous hypothyroidism 4 | Alliance | Hypothyroidism, congenital, nongoitrous 4 | 275100 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cystine-knot cytokine | Glycoprotein hormone subunit beta | Gonadotropin, beta subunit | Gonadotropin, beta subunit, conserved site |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PZI4
|
129 | ||||
|
UniProtKB:Q801K4
|
148 | ||||
|
UniProtKB:A0A8M9PLW7
|
182 |
Interactions and Pathways
No data available
Plasmids
No data available