IMAGE

Fig 8

ID

ZDB-IMAGE-191230-665

Genes

ckmb
myom1a

Publication

Prill et al., 2019 - Myomesin is part of an integrity pathway that responds to sarcomere damage and disease

All Figures

Figures for Prill et al., 2019

Image

Figure Caption

Fig 8 <italic>Myomesin1a</italic> is significantly upregulated at early stages of myogenesis in muscle mutants.

qPCR analysis at 19, 24 and 48 hpf revealed a statistically significant up-regulation of myom1a expression in smyd1b^tm123a, unc45b^sb60 and titin2^tg287 mutants relative to wild-type embryos at identical stages (A). At 24 hpf, in situ hybridization demonstrated somite-restricted myom1a expression in wild-type siblings (B), which is increased in smyd1b^tm123a embryos (C). At 24 hpf, wild-type (D) and smyd1b^tm123a (E) embryos display similar levels of muscle creatine kinase b (ckmb) expression in their skeletal muscle. Compared to wild-type embryos at 24 hpf (D), unc45b^sb60 (H) and titin2^tg287 (J) show a significant decrease in ckmb expression. At 48 hpf, smyd1b^tm123a (G), unc45b^sb60 (I) and titin2^tg287 (K) embryos demonstrated increased ckmb expression in their skeletal muscle when compared to wild-type siblings (E). (Error bars are standard deviation. Expression is normalized using ef1a and wild-type at corresponding stages).

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One