ZFIN Image: Rogers et al., 2017, Fig. 3

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Figure Caption

Fig. 3

Lefty loss causes expanded expression of mesendodermal genes.

In situ hybridization comparing expression of endodermal (sox32/casanova) (A–E’’’) and mesodermal (noto/floating head) (F–J’’’) genes in wild type, lft1^-/- mutants, lft2^-/- mutants, and lft1^-/-;lft2^-/- mutants at the indicated developmental stages (dorsal views). Note upregulation of mesendoderm in lft1^-/-;lft2^-/- mutants starting at early gastrulation stages (e.g., shield stage). lft1^-/-;lft2^-/- embryos were generated from lft1^+/-;lft2^-/- incrosses, lft1^-/-;lft2^-/- incrosses, or lft1^-/-;lft2^-/- X lft1^+/-;lft2^-/- crosses. Embryos were genotyped after imaging (see Materials and methods for details).

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Acknowledgments

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