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ZDB-IMAGE-171201-31

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Khatri et al., 2016 - Down-regulation of coasy, the gene associated with NBIA-VI, reduces Bmp signaling, perturbs dorso-ventral patterning and alters neuronal development in zebrafish

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Fig. 5

Analysis of neurog1, pax2a and gata2a neural markers in coasy morphants.

Representative images of WISH analyses with neurog1, pax2a and gata2a riboprobes. neurog1 in ST-MO- (a), and coasy-MO-injected embryos (b) at 24 hpf, lateral views. Pax2a expression in ST-MO- (c), and coasy-MO-injected embryos (d) at 15 hpf, lateral views. Gata2a expression in ST-MO- (e,f), and coasy-MO-injected embryos (g,h) at 17 hpf (e,f lateral views and g,h dorsal views). Results are from one representative experiment with at least 40 embryos out of two independent replicates. Abbreviations: d, diencephalon; hb, hindbrain; mhb, midbrain-hindbrain boundary; os optic stalk; ov, otic vesiscle; pd, pronephritic ducts.

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