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Zhu et al., 2017 - Vegfa Impacts Early Myocardium Development in Zebrafish

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Fig. 1

Vascular endothelial growth factor Aa (vegfaa) deficiency disrupts myocardial and endocardial morphogenesis. (A–I) Fluorescence micrographs of the hearts of wild-type (A–C), vegfaa mutant (D–F), and vegfaa morphants (G–I) at 96 hpf (hours post-fertilization) with the background of Tg(myl7:mCherry)/Tg(kdrl:EGFP) transgenic fish. The whole heart is substantially small and linearized in the mutant and the morphant, and no cavity is visible inside the heart lumen. Scale bar: 50 μm (A– I); (J,K) In situ hybridization of vegfaa in wild-type embryos at 18-somite stage. vegfaa is expressed in anterior lateral plate mesoderm as indicated by the arrow. (J) Lateral views, (K) Dorsal views with the anterior at the top. Scale bar: 200 μm (J,K). WT, wild-type; mo, morpholino

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.